Tatlisu is a village in Famagusta District, on the northern coast of Cyprus. As of 2011, it had a population of 1,459.
The first settlement that can be linked with the modern-day Tatlisu village was in the Kouphes area, 2 miles to the northwest of Tatlisu. Tatlisu was established between the 7th and the 10th century at the place where the river passing through the village meets the sea. Following the Mamluk Arab raids in Cyprus, the coastal location was abandoned and the village moved to its present-day inland location. The name Akanthou in greek, according to local tradition, comes from the name of a thorny bush present in the area, which is said to have provided protection for a beautiful woman, Anthousa, who the Arab sailors tried to take captive.
Tatlisu was recorded to be under the fiefdom of a nobleman called Sir John Gorap in 1385. In the 14th and 15th centuries, there are records that indicate that Tatlisu hosted royal casalia of the Kingdom of Cyprus as well as sugar plantations.
It was the place of landing for Ottoman troops under Çıfıtoğlu Ahmet Pasha that came to Cyprus to suppress the rebellion headed by Boyacıoğlu Mehmet Agha against Ottoman rule between 1680 and 1687/88. General Louis Palma di Cesnola wrote in 1877 that the village relied on its production of halloumi. Around 2 million halloumis were produced each year in the caves around the village and exported to cities abroad such as Smyrna, Port Said and Alexandria.